Research Interests

Cell biology; Cellular pathology; Histopathology; Molecular biology; Molecular cancer therapeutics; Molecular oncology; Pathophysiology; Pharmacodynamics; Use of synthetic compounds and traditional Chinese medicines for anti-cancer studies

My long-term research goals are to determine the novel molecular mechanisms of carcinogenesis mainly in human esophageal squamous cell carcinoma, and to explore the new protocols for cancer treatments. Various research approaches have been applied for achieving the goals:

1. To explore the novel application of different types of synthetic compounds and traditional Chinese medicines for cancer treatments, with the consideration of new combinations to the routine chemotherapeutic protocols;

2. To investigate the molecular mechanisms of different synthetic compounds and traditional Chinese medicines for their anti-cancer actions.

3. To establish and characterize tumor cell lines of different tissue origins from Chinese population. The availability of well-characterized tumor cell lines ensures the sources and qualities for the subsequent in vitro molecular and pharmacological studies on different tumors;

4. To establish the nude mouse-xenograft models of different tumors as the tools for the subsequent ex vivo studies on various human tumors in pharmacological, histopathological and molecular aspects;

5. To apply various modern molecular biology techniques for studying the primary tumors, their xenografts and the corresponding tumor cell lines on their genomic alterations, gene expression profiles and novel candidate genes involved in molecular carcinogenesis.

6. To correlate the clinicopathological features of the primary tumors with their molecular characteristics.
   

Selected Publications

          Selected Journal Articles:

Hau DKP, Gambari R, Wong RSM, Cheng GYM, Tong CZW, Zhu GY, Leung A, Cheung F, Lau FY, Chan AKW, Kok SHL, Chan ASC, Chui CH, Tang JCO*, Fong WF*. Phyyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1. Phytomedicine  (in press)


Lam KH, Chui CH, Chan SH, Gambari R, Yuen MCW, Tao XM, Xu L, Tang W, Cheng GYM, Wong RSM, Lau FY, Lai PBS, Kok SHL, Lam WS, Tang JCO*, Chan ASC*. The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents. Bioorganic & Medicinal Chemistry Letters (in press)


Pak KC, Lam KY, Law S, Tang JCO*. The inhibitory effect of Gleditsia sinensis on cyclooxygenase-2 expression in human esophageal squamous cell carcinoma. International Journal of Molecular Medicine 23(1):121-129 (2009)


Liu QJ, Yu JJ, Xiao L, Tang JCO, Zhang Y, Wang P, Yang M. Impedance studies of bio-behavior and chemosensitivity of cancer cells by micro-electrode arrays. Biosensors & Bioelectronics 34(5):1305-1310 (2009)


Chan SH, Lam KH, Chui CH, Gambari R, Yuen MCW, Wong RSM, Cheng GYM, Lau FY, Au YK, Cheng CH, Kok SHL, Tang JCO*, Chan ASC*. The preparation and in vitro antiproliferative activity of
phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines. European Journal of Medicinal Chemistry [Epub ahead of print] (5 Nov 2008)


Lu GL, Ho CL, Wang QW, Wong WY, Chui CH, Wong RSM, Gambari R, Lau FY, Yuen MCW, Tong CSW, Chan AKW, Tang JCO, Ho KP, Cheng GYM. Synthesis and Characterization of Some Metal Complexes of 4,5-Diazafluoren-9-one and their Biological Effects on Human Carcinoma Cells. Australian Journal of Chemistry 61(12):975-980 (2008)


Kok SHL, Wong RSM, Gambari R, Cheung F, Lam WS, Lau FY, Cheng GYM, Cheng CH, Lam KH, Chan SH, Tang JCO, Chui CH, Ho KP. In vitro cytotoxicity of (-)-EGCG octaacetate on MDAMB-231 and SKHep-1 human carcinoma cells: A pharmacological consideration on prodrug design. International Journal of Molecular Medicine 22(6):841-845 (2008)


Kok SHL, Gambari R, Chui CH, Yuen MCW, Lin E, Wong RSM, Lau FY, Cheng GYM, Lam WS, Chan SH, Lam KH, Cheng CH, Lai PBS, Yu MWY, Cheung F, Tang JCO*, Chan ASC*. Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines. Bioorganic & Medicinal Chemistry 16(7):3626-3631 (2008)


Ko JMY, Chan PL, Yau WL, Chan HK, Chan KC, Yu ZY, Kwong FM, Miller LD, Liu ET, Yang LC, Lo PHY, Stanbridge EJ, Tang JCO, Srivastava G, Tsao SW, Law S, Lung ML. Monochromosome transfer and microarray analysis identify a critical tumor suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma. Molecular Cancer Research 6(4):592-603 (2008)


Cheng SY, Yuen CWM, Kan CW, Cheuk KKL, Tang JCO. Analysis of keratin fibre damages. Textile Asia Dec 07-Jan 08: 60-64 (2008)


Cheung LCM, Tang JCO, Lee PY, Hu L, Guan XY, Tang WK, Srivastava G, Wong J, Luk J, Law S. Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of Chinese origin. Cancer Genetics and Cytogenetics, 178(1):17-25 (2007)


Law FBF, Chen YW, Wong KY, Ying J, Tao Q, Langford C, Lee PY, Law S, Cheung RWL, Chui CH, Tsao GSW, Lam KY, Wong J, Srivastava G, Tang JCO*. Identification of a novel tumor transforming gene GAEC1 at 7q22 which encodes a nuclear protein and is frequently amplified and overexpressed in esophageal squamous cell carcinoma. Oncogene, 26(40):5877-5888 (2007)


Kok SHL, Gambari R, Chui CH, Lau FY, Cheng GYM, Lai PBS, Lam WS, Chan ASC, Cheng CH, Teo ITN, Yu MWY, Tang JCO, Cheung F, Wong RSM. Paradoxical proliferative potential of iron (II) sulphate on cancer cells after the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2Htetrazolium (MTS) assay. International Journal of Molecular Medicine, 19(6):971-975 (2007)


Kok SHL, Chui CH, Lam WS, Chen J, Lau FY, Wong RSM, Cheng GYM, Lai PPS, Leung TWT, Yu MWY, Tang JCO*, Chan ASC*. Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep1 hepatoma cells. Bioorganic & Medicinal Chemistry Letters, 17(5), 1155-1159 (2007)


Tang WK, Chui CH, Fatima S, Kok SHL, Pak KC, Ou TM, Hui KS, Wong MM, Wong J, Law S, Tsao SW, Lam KY, Beh PHL, Srivastava G, Ho KP, Chan ASC, Tang JCO*. Inhibitory effects of Gleditsia sinensis fruit extract on telomerase activity and oncogenic expression in human esophageal squamous cell carcinoma. International Journal of Molecular Medicine, 19(6):953-960 (2007)


Tang WK, Chui CH, Fatima S, Kok SHL, Pak KC, Ou TM, Hui KS, Wong MM, Wong J, Law S, Tsao SW, Lam KY, Beh PSL, Srivastava G, Chan ASC, Ho KP, Tang JCO*. Oncogenic properties of a novel gene (JK-1) located in chromosome 5p and its overexpression in human esophageal squamous cell carcinoma. International Journal of Molecular Medicine, 19(6):915-923 (2007)


Ou TM, Lu YJ, Zhang C, Huang ZS, Wang XD, Tan JH, Chen Y, Ma DL, Wong KY, Tang JCO, Chan ASC, Gu LQ. Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives. Journal of Medicinal Chemistry, 50(7):1465-1467 (2007)


Lo PHY, Leung ACC, Kwok CYC, Cheung WSY, Ko JMY, Yang LC, Law S, Wang LD, Li J, Stanbridge EJ,  Srivastava G, Tang JCO, Tsao SW, Lung ML. Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9. Oncogene, 26(1), 148-157 (2007)


Chui CH*, Gambari R, Kok SHL, Lau FY, Wong RSM, Cheng GYM, Ho KP, Cheung F, Chan SSW, Cheng CH, Chan ASC, Tang JCO*. Anti-bacterial and wound repair potentials of a novel microbial fermentation product (Invited Review Article).  Minerva Biotecnologica, 18(4), 181-184 (2006)


Kok SHL, Gambari R, Chui CH*, Lam WS, Chen J, Lau FY, Wong RSM, Cheng GYM, Lai PBS, Leung TWT, Chan ASC, Tang JCO*. In vitro anti-cancer property of five synthetic cantharidin analogues: a mini-review (Invited Review Article) . Minerva Biotecnologica, 18(3), 153-157 (2006)


Kok SHL, Chui CH, Lam WS, Chen J, Lau FY, Wong RSM, Cheng GYM, Tang WK, Teo ITN, Cheung F, Cheng CH, Chan ASC*, Tang JCO*. Apoptogenic activity of a synthetic cantharimide in leukaemia: Implication on its structural activity relationship. International Journal of Molecular Medicine, 18(6),  1217-1221 (2006)


Chui CH, Wong RSM, Cheng GYM, Lau FY, Kok SHL, Cheng CH, Cheung F, Tang WK, Teo ITN, Chan ASC. Tang JCO*. Antiproliferative ability of a combination regimen includes crocodile egg extract, wild radix ginseng and natural ganoderma lucidum on acute myelogenous leukemia. Oncology Reports, 16(6), 1313-1316 (2006)


He YH, Zhou J, Wang YS, Xiao C, Tong Y, Tang JCO, Chan ASC, Lu AP. Anti-inflammatory and anti-oxidative effects of cherries on Freund's adjuvant-induced arthritis in rats. Scandinavian Journal of Rheumatology, 35(5), 356-358 (2006)


Chui CH, Gambari R, Lau FY, Hau DKP, Wong RSM, Cheng GYM, Kok SHL, Higa T, Ke B, Chan ASC, Fong DWF, Tang JCO*. Antiangiogenic activity of concentrated effective microorganism fermentation extract. International Journal of Molecular Medicine, 18(5), 975-979 (2006)


Xian C, Lu C, Zhao L, Liu Z, Zhang W, He Y, Chen S, Tang JCO, Chan ASC, Lu AP. The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis. Planta Medica, 72(14), 1268-1272 (2006)


Kok SHL, Chui CH, Lam WS, Chen J, Lau FY, Wong RSM, Cheng GYM, Tang WK, Cheng CH, Tang JCO*, Chan ASC*. Mechanistic insight of  a novel synthetic cantharidin analogue on leukaemia model. International Journal of Molecular Medicine, 18(2), 375-380 (2006)


Kok SHL, Chui CH, Lam WS, Chen J, Lau FY, Cheng GYM, Wong RSM, Lai PPS, Leung TWT, Tang JCO*, Chan ASC*. Apoptotic activity of a novel synthetic cantharidin analogue on hepatoma cell lines. International Journal of Molecular Medicine, 17(5):945-949 (2006)


Chui CH, Gambari R, Lau FY, Cheng GYM, Wong RSM, Kok, SHL, Tang JCO*, Teo ITN, Cheung F, Cheng CH, Ho KP, Chan ASC, Wong A. In vitro anti-cancer activity of a novel microbial fermentation product on human carcinomas. International Journal of Molecular Medicine, 17(4), 675-679 (2006)


Wong MLY, Tao Q, Fu L, Wong KY, Qiu GH, Law FBF, Tin PC, Cheung WL, Lee PY, Tang JCO, Tsao GSW, Lam KY, Law S, Wong J, Srivastava G. Aberrant promoter hypermethylation and silencing of the critical 3p21 tumor suppressor gene, RASSF1A, in Chinese oesophageal squamous cell carcinoma.  International Journal of Oncology, 28(3), 767-773 (2006)


Zhou J, Xiao C, Zhao L, Jia H, Zhao N, Lu C, Yang D, Tang JCO, Chan ASC, Lu AP. The effect of triptolide on CD4+ and CD8+ cells in Peyer’s patch of SD rats with collagen induced arthritis. International Immunopharmacology, 6(2), 198-203 (2006)


Chui CH, Hau DKP, Lau FY, Cheng GYM, Wong RSM, Gambari R, Kok SHL, Lai KB, Teo ITN, Leung TWT, Higa T, Ke Bin, Tang JCO*, Fong DWF, Chan ASC. Apoptotic potential of the concentrated effective microorganism fermentation extract on human cancer cells. International Journal of Molecular Medicine, 17(2), 279-284 (2006)


Kok SHL, Chui CH, Lam WS, Chen J, Tang JCO*, Lau FY, Cheng GYM, Wong RSM, Chan ASC. Induction of apoptosis on carcinoma cells by two synthetic cantharidin analogues. International Journal of Molecular Medicine, 17(1), 151-158 (2006)


Fatima S, Chui CH, Tang WK, Hui KS, Au HW, Li WY, Wong MM, Cheung F, Tsao SW, Lam KY, Beh PSL, Wong J, Law S, Srivastava G, Ho KP, Chan ASC,  Tang JCO*. Transforming capacity of two novel genes JS-1 and JS-2 in chromosome 5p and their overexpression in human esophageal squamous cell carcinoma. International Journal of Molecular Medicine, 17(1), 159-170 (2006)


He YH, Zhou J, Wang YS, Xiao C, Tong Y, Tang JCO, Chan ASC, Lu AP. Immunomodulation and antioxidant effects of anthocyanins from cherries on adjuvant-induced arthritis in rats. Evidence-Based Integrative Medicine, 2(2), 95-100 (2005)


Chui CH, Gambari R, Lau FY, Teo ITN, Ho KP, Cheng GYM, Ke B, Higa T, Kok HL, Chan ASC, Tang JCO. Anti-cancer potential of traditional Chinese herbal medicines and microbial fermentation products (Invited Review Article). Minerva Biotecnologica, 17(3), 183-191 (2005)


Lau FY, Chui CH, Gambari R, Kok SHL, Kan KL, Cheng GYM, Wong RSM, Teo ITN, Cheng CH, Wan TSK, Chan ASC, Tang JCO*. Antiproliferative and apoptosis-inducing activity of Brucea javanica extract on human carcinoma cells. International Journal of Molecular Medicine, 16(6), 1157-1162 (2005)


Teo ITN, Chui CH, Tang JCO*, Lau FY, Cheng GYM, Wong RSM, Kok SHL, Cheng CH, Chan ASC, Ho KP. Antiproliferation and induction of cell death of Phaffia rhodozyma (Xanthophyllomyces dendrorhous) extract fermented by brewer malt waste on breast cancer cells. International Journal of Molecular Medicine, 16(5), 931-936 (2005)


Cheung F, Chui CH, Chan ASC, Lau FY, Cheng GYM, Wong RSM, Kok SHL, Teo ITN, Cheng CH, Tang JCO*. Inhibition of proteasome activity in Gleditsia sinensis fruit extract-mediated apoptosis on human carcinoma cells. International Journal of Molecular Medicine, 16(5), 925-929 (2005)


Chui CH, Lau FY, Tang JCO*, Kan KL, Lau PM, Cheng GYM, Wong RSM, Kok SHL, Lai PBS, Ho R, Gambari R, Chan ASC. Activities of fresh juice of Scutellaria barbata and warmed water extract of Radix Sophorae Tonkinensis on anti-proliferation and apoptosis of human cancer cell lines. International Journal of Molecular Medicine, 16(2), 337-341 (2005)


Ko JMY, Yau WL, Chan PL, Lung HL, Yang LC, Lo PHY, Tang JCO, Srivastava G, Stanbridge EJ, Lung ML. Functional evidence of decreased tumorigenicity associated with monochromosome transfer of chromosome 14 in esophageal cancer and mapping of tumor-suppressive regions to 14q32. Genes, Chromosomes & Cancer, 43(3), 284-293 (2005)


Chui CH, Lau FY, Chan ASC, Cheng GYM, Wong RSM, Lai KB, Kok SHL, Au Yeung TL, Teo ITN, Yau MYC, Cheng F, Cheng CH, Tang JCO*. Gleditsia sinensis fruit extract induced apoptosis involves changes of reactive oxygen species level, mitochondrial membrane depolarization and caspase 3 activation.  International Journal of Molecular Medicine, 15(3), 539-543 (2005)


Yang LC, Leung ACC, Ko JMY, Lo PHY, Tang JCO, Srivastava G, Oshimura M, Stanbridge EJ, Daigo Y, Nakamura Y, Tang CMC, Lau KW, Law S, Lung ML. Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma. Oncogene, 24(4), 697-705 (2005)


Chui CH, Cheng GYM, Ke B, Lau FY, Wong RSM, Kok SHL, Fatima S, Cheung F, Cheng CH, Chan ASC, Tang JCO*. Growth inhibitory potential of effective microorganism fermentation extract (EM-X) on cancer cells. International Journal of Molecular Medicine, 14(5), 925-929 (2004)


Kwong FM, Tang JCO, Srivastava G, Lung ML. Inactivation mechanisms and growth suppressive effects of p16INK4a in Asian esophageal squamous carcinoma cell lines. Cancer Letters, 208(2), 207-213 (2004)


Teo ITN, Tang JCO*, Chui CH, Cheng GYM, Yau MYC, Lau FY, Wong RSM, Leung TWT, Cheung F, Ho KP, Cheng CH, Chan ASC. Superoxide anion is involved in the early apoptosis mediated by Gleditsia sinensis extract. International Journal of Molecular Medicine, 13(6), 909-913 (2004)


Chui CH, Tang JCO*, Lau FY, Teo ITN, Yau MYC, Wong RSM, Cheng GYM, Ho SKW, Leung TWT, Hui KS, Wong MM, Fatima S, Cheng CH, Cheung F, Tan WQ, Chow LMC, Guo DA, Chan ASC. Gleditsia sinensis fruit extract induced growth inhibition involves basic fibroblast growth factor and nitric oxide. International Journal of Molecular Medicine, 13(1), 169-173 (2004)


Shen LJ, Liang ACT, Au WY, Lu LW, Chen YW, Wong KY, Tang JCO, Chan KW, Beh SL, Kwong YL, Liang RHS, Srivastava G. BCL10 mutations are irrelevant to its aberrant nuclear localization in nasal NK/T-cell lymphoma. Leukemia, 17(11), 2240-2242 (2003)


Chen YW, Liang ACT, Au WY, Chu KM, Wong KY, Hu XT, Lu LW, Tang JCO, Chan KW, Beh SL, Kwong YL, Liang RHS, Srivastava G. Multiple BCL6 translocation partners in individual cases of gastric lymphoma. Blood, 102(5), 1931-1932 (2003)


Shen LJ, Liang ACT, Lu LW, Au WY, Wong KY, Tin PC, Chan KW, Ko KH, Chen YW, Beh SL, Shimizu N, Tsuchiyama J, Tang JCO, Kwong YL, Liang RHS, Srivastava G. Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma. Blood, 102(4), 1553-1554 (2003)


Chow LMC, Chui CH, Tang JCO, Teo I, Lau FY, Cheng GYM, Wong RSM, Leung TWL, Lai KB, Yau M, Guo DA, Chan ASC. Gleditsia sinensis fruit extract is a potential chemotherapeutic agent in chronic and acute myelogenous leukemia. Oncology Reports, 10(5),1601-1607 (2003)


Chow LMC, Chui CH, Tang JCO, Lau FY, Yau MYC, Cheng GYM, Wong RSM, Lai PPS, Leung TWT, Teo I, Cheung F, Guo DA, Chan ASC. Anti-angiogenic potential of Gleditsia sinensis fruit extract. International Journal of Molecular Medicine, 12(2), 269-273 (2003)


Chow LMC, Tang JCO, Teo ITN, Chui CH, Lau FY, Leung TWT, Cheng G, Wong RSM, Wong ILK, Tsang KMS, Tan WQ, Zhao YZ, Lai KB, Lam WH, Guo DA, Chan ASC. The anti-proliferative activity of extract from Gleditsia sinensis fruit on human solid tumour cell lines. Chemotherapy, 48(6), 303-308 (2002)


Tang JCO, Lam KY, Law S, Wong J, Srivastava G. Detection of genetic alterations in esophageal squamous cell carcinomas and adjacent normal epithelia by comparative DNA fingerprinting using inter-simple sequence repeat PCR. Clinical Cancer Research, 7(6), 1539-1545 (2001)


Tang JCO, Wan TSK, Ma SK, Chan LC, Wong N, Pang E, Law S, Wong J, Chow LMC, Lam KY, Srivastava G. Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line SLMT-1 of Chinese origin. Cancer Genetics and Cytogenetics, 124(1), 36-41 (2001)


Leung TWT, Cheng G, Chui CH, Ho SKW, Lau FY, Tjong JKJ, Poon TCC, Tang JCO, Tse WCP, Cheng KF, Kong YC. Yuehchukene (a bis-indole alkaloid) and cyclophosphamide are active in breast cancer in vitro. Chemotherapy, 46(1), 62-68 (2000)


Hu YC, Lam KY, Tang JCO, Srivastava G. Mutation analysis of the PTEN/MMAC1 gene in primary esophageal squamous cell carcinomas. Journal of Clinical Pathology-Molecular Pathology, 52(6), 353-356 (1999)


Tang JCO, Ho FCS, Chan ACL, Chow EYW, Srivastava G. Progression of spontaneous lymphomas in SJL mice: monitoring in vivo clonal evolution with molecular markers in sequential splenic samples. Laboratory Investigation, 78(11), 1459-1466 (1998)


Tang JCO, Ho FCS, Chan ACL, Srivastava G. Clonality of lymphomas at multiple sites in SJL mice. Laboratory Investigation, 78(2), 205-212 (1998)


Chui CH, Lau FY, Chan AHC, Tang JCO, Hui CH, Lam CCK, Chan LC, Cheng G. Expression of an abnormally sized c-kit transcript in Hong Kong Chinese acute lymphoblastic leukaemia patients. Clinical & Laboratory Haematology, 18(4), 261-263 (1996)

*corresponding author

Selected Conference Papers:

Cheng SY, Yuen CWM, Kan CW, Cheuk KLK, Tang JCO. Systemic characterization for cosmetic textiles. Proceedings at the 37th Textile Research Symposium, Daegu, Korea, Aug 20-23, 2008


Pak KC, Chui CH, Tang WK, Fatima S, Lui CY, Liu D, Lam KY, Wong TK, Choi YS, Law S, Lam KY, Srivastava G, Tang JCO. The inhibitory effect of Gleditsia sinensis and quindoline derivatives on cyclooxygenase-2 in human esophageal squamous cell carcinoma. Proceedings at the 14th Hong Kong International Cancer Congress, Hong Kong, Nov 14-16, 2007


Chui CH, Kok SHL, Ou TM, Gu LQ, Wong J, Law S, Tang JCO.  Inhibitory  actions of quinoline derivatives on esophageal carcinoma. Proceedings at the 13th Hong Kong International Cancer Congress, Hong Kong, Nov 15-17, 2006


Tang WK, Fatima S, Chui CH, Ou TM, Hui KS, Wong MM, Wong J, Law S, Tsao GSW, Lam KY, Beh PSL, Srivastava G, Ho KP, Tang JCO. Oncogenic properties of a novel gene located in chromosome 5p and its overexpression in human esophageal squamous cell carcinoma. Proceedings at the 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress of Biochemistry and Molecular Biology,  Kyoto, Japan, June 18-23, 2006


Chui CH, Gambari R, Wong RSM, Cheng GYM, Lau FY, Kok SHL, Tang WK, Chan ASC, Tang JCO. Antiproliferative ability of a combination regimen includes crocodile egg extract, wild radix ginseng and natural Ganoderma lucodium on acute myelogenous leukemia. Proceedings at the 4th International Conference on Natural Products, Leysin, Switzerland, May 28-31, 2006


Chui CH, Kok SHL, Lau FY, Gambari R, Wong RSM, Cheng GYM, Lam WS, Chen J, Chan ASC, Tang JCO. Identification of cantharidin analogues with anti-cancer property. Proceedings at the 4th International Conference on Natural Products, Leysin, Switzerland, May 28-31, 2006


Tang WK, Tang JCO. Overexpression and transforming capacity of a novel gene JK-1 in human esophageal squamous cell carcinoma. Proceedings at the 97th Annual Meeting, American Association for Cancer Research, Washington, DC, USA, April 1-5, 2006


Lau FY, Chui CH, Tang WK, Gambari R, Kok SHL, Kan KL, Cheng GYM, Wong RSM, Teo ITN, Cheng CH, Wan TSK, Chan ASC, Tang JCO. Anti-cancer effects of Brucea javanica on human carcinoma cells. Proceedings at the 12th Hong Kong International Cancer Congress and 2nd Annual Meeting of the Centre for Cancer Research, Hong Kong, December 8-10, 2005


Chui CH, Lau FY, Cheng GYM, Wong RSM, Kok SHL, Chan ASC, Tang JCO. Anti-cancer potential of traditional Chinese medicine extracts. Proceedings at the 10th World Congress on Advances in Oncology and 8th International Symposium on Molecular Medicine, Hersonissos, Crete, Greece, October 13-15, 2005


Fatima S, Hui KS, Wong MM, Tang WK, Chui CH, Wong J, Law S, Tsao GSW, Srivastava G, Ho KP, Tang JCO. Study of transforming capacity of two novel genes JS-1 and JS-2 in chromosome 5p and their overexpression in human esophageal squamous cell carcinoma. Proceedings at the 96th Annual Meeting, American Association for Cancer Research, Anaheim, CA, USA, April 16-20, 2005


Chui CH, Tang JCO, Lau FY, Cheng GYM, Wong RSM, Teo ITN, Chan ASC. Anti-cancer potential of Gleditsia sinensis fruit extract. Proceedings at the 9th World Congress on Advances in Oncology and 7th International Symposium on Molecular Medicine, Hersonissos, Crete, Greece, October 14-16, 2004


Lau FY, Chui CH, Cheng GYM, Ke B, Wong RSM, Teo ITN, Fatima S, Kok SHL, Chan ASC, Tang JCO. Growth inhibitory potential of effective microorganisms fermentation extract (EM-X) on cancer cells. Proceedings at the 9th World Congress on Advances in Oncology and 7th International Symposium on Molecular Medicine, Hersonissos, Crete, Greece, October 14-16, 2004


Yang LC, Tang JCO, Srivastava G, Stanbridge EJ, Lung ML. Functional investigation of tumor suppressive role of chromosome 9 in esophageal squamous cell carcinoma. Proceedings at the 40th Annual Meeting, American Society of Clinical Oncology, New Orleans, Louisiana, USA, June 5-8, 2004


Lung ML, Lo PH, Tang JCO, Srivastava S, Stanbridge EJ. Functional localization of tumor suppressive regions on chromosome 3 in esophageal carcinoma. Proceedings at the 95th Annual Meeting, American Association for Cancer Research, Orlando, Florida, USA, March 27-31, 2004


Law FBF, Srivastava G, Chen YW, Liang ACT, Wong KY, Lam KY, Law S, Wong J, Tang JCO. A novel tumor transforming gene at 7q22, GAESCC1, is frequently amplified and overexpressed in primary esophageal squamous cell carcinomas. Proceedings at the 95th Annual Meeting, American Association for Cancer Research, Orlando, Florida, USA, March 27-31, 2004


Chui CH, Tang JCO, Lau FY, Wong RSM, Cheng GYM, Hui KS, Wong MM, Fatima S, Chow LMC, Gou DA, Chan ASC. Basic fibroblast growth factor and nitric oxide are involved in the growth inhibition induced by Gleditsia sinensis fruit extract. Proceedings at the 10th Hong Kong International Cancer Congress, Hong Kong, Nov 19-21, 2003


Tang JCO, Hu YC, Law BF, Wong KY, Hu L, Guan XY, Lam KY, Law S, Wong J, Srivastava G. Molecular pathogenesis of human esophageal squamous cell carcinomas. Proceedings at the 9th Hong Kong International Cancer Congress, Hong Kong, Dec 8-11, 2002


Tang JCO, Wan TSK, Wong N, Pang E, Lam KY, Law SY, Chow LMC, Ma ESK, Chan LC, Wong J, Srivastava G. Establishment and characterization of a new xenograft-derived human oesophageal squamous cell carcinoma cell line SLMT-1 of Chinese origin. Proceedings at the 7th Hong Kong International Cancer Congress, Hong Kong, Dec 7-9, 2000


Tang JCO, Lam KY, Law S, Wong J, Srivastava G. Detection of genetic alterations in esophageal squamous cell carcinoma tumor specimens and adjacent normal epithelia by comparative DNA fingerprinting using inter-simple sequence repeat PCR. Proceedings at the 7th Hong Kong International Cancer Congress, Hong Kong, Dec 7-9, 2000


Lam AWH, Chow LMC, Tang JCO, Chui CH, Chan ASC. In vitro cytotoxicity analysis of Yuehchukene (YCK) analogues to estrogen receptor positive breast cancer cell line (MCF-7). Proceedings at the 1st Hong Kong Symposium on Chirotechnology, Hong Kong, Aug 21-23, 2000


Tang JCO, Ho FCS, Srivastava G. Clonality of lymphomas at multiple sites and tumour progression in SJL mice. Proceedings at the 2nd Hong Kong International Cancer Congress, Hong Kong, Nov 17-19, 1995


Tang JCO, Srivastava G, Chan ACL, Ho FCS. A study of SJL lymphomas using immunoglobulin gene rearrangements and murine leukaemia virus integrations as clonal markers. Proceedings at the 20th International Congress of the International Academy of Pathology & 11th World Congress of Academic and Environmental Pathology, Hong Kong, Oct 9-14, 1994